In 2010, Murray played Alicia Keys's love interest in her music video for "Un-Thinkable (I'm Ready)".
Then he played Ethan Mc Allister in Lifetime's TV movie Lies in Plain Sight.
The series was The WB's most successful and top rated television program when it first aired in 2003 and continued receiving top ratings for The CW.
The series also earned Murray numerous awards, including two Teen Choice Awards, and spawned a book series which was successful among critics who praised the cast's performances and the original story lines.
Though the reviews were mostly negative, the film went on to become a moderate box office success, earning .1 million worldwide.
The film led to 2005 Teen Choice Awards wins in several categories. Though most film critics gave the film negative reviews, House of Wax earned over ,766,121 worldwide.
He appeared in several guest starring television roles, including an episode of Undressed and an episode of Diagnosis: Murder.
Murray portrayed the role Charlie Todd on the successful television series Dawson's Creek in 2001.
Murray then appeared in the Walt Disney Pictures feature film, Freaky Friday alongside Lindsay Lohan and Jamie Lee Curtis.That same year, he was voted as one of "TV's Sexiest Guys" in People magazine.In 2004, Murray starred in the romantic comedy A Cinderella Story with Hilary Duff.After Murray gained mainstream fame and media exposure, he also became a spokesperson for several high-profile deals.He and his One Tree Hill co-stars were the official endorsers for Master Card and K-Mart.